| アイテムタイプ |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2021-03-25 |
| タイトル |
|
|
タイトル |
糖尿病誘発性慢性腎疾患モデル動物―尿細管障害バイオマーカーによる検討― |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
An animal model of diabetes-induced chronic kidney disease―Study with special reference to tubule injury biomarkers― |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
|
|
ID登録 |
10.14993/00002037 |
|
ID登録タイプ |
JaLC |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
保井, 俊英
花岡, 智子
高田, 義弘
竹下, 大輔
鷲尾, 弘枝
進藤, 大典
中谷, 昭
坂田, 進
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Diabetes-induced chronic kidney disease（DCKD） is a serious health problem. Therefore, modalities for preventing/improving DCKD are required. The aim of this study was to establish an animal model of DCKD. Four five-week-old male OLETF and LETO rats were used as experimental and control animals, respectively. After both rats were raised 17 months, collections of urine, blood and bilateral kidneys were performed. Urinary biomarkers for renal proximal tubule injury, monocyte chemoattractant protein-1（MCP-1） and kidney injury molecule-1（KIM-1）, were measured by the Bio-Plex system. OLETF rats showed a significant increase in blood glucose, Hb A1c, creatinine, blood urea nitrogen（BUN）, kidney/body weight ratio, glomerular area, 24 h-urine volume, urinary protein concentrations, MCP-1 and KIM-1 compared with LETO rats. There was a positive correlation not only between BUN and MCP-1 or KIM-1 but also between urinary protein concentrations and MCP-1 or KIM-1. These results indicate that the present OLETF rats have both glomerular and proximal tubular injury. Thus, the aged male OLETF rats with long-term diabetes may become a potent animal model for examining effects of exercise/dietary therapies on DCKD. |
|
言語 |
en |
| 書誌情報 |
ja : 武庫川女子大学紀要
en : The bulletin of Mukogawa Women's University
巻 68,
p. 55-61,
発行日 2021-03-12
|
| 出版者 |
|
|
出版者 |
武庫川女子大学 |
|
言語 |
ja |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
2435-4848 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2759-2650 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12889706 |
P55-61.pdf (1.0 MB)
