@article{oai:mukogawa.repo.nii.ac.jp:00002076,
 author = {保井, 俊英 and YASUI, Toshihide and 花岡, 智子 and HANAOKA, Tomoko and 高田, 義弘 and TAKADA, Yoshihiro and 竹下, 大輔 and TAKESHITA, Daisuke and 鷲尾, 弘枝 and WASHIO, Hiroe and 進藤, 大典 and SHINDO, Daisuke and 中谷, 昭 and NAKATANI, Akira and 坂田, 進 and SAKATA, Susumu},
 journal = {武庫川女子大学紀要},
 month = {Mar},
 note = {Diabetes-induced chronic kidney disease（ DCKD） is a serious health problem. Therefore, modalities for preventing/improving DCKD are required. The aim of this study was to establish an animal model of DCKD. Four five-week-old male OLETF and LETO rats were used as experimental and control animals, respectively. After both rats were raised 17 months, collections of urine, blood and bilateral kidneys were performed. Urinary biomarkers for renal proximal tubule injury, monocyte chemoattractant protein-1（ MCP-1） and kidney injury molecule-1（ KIM-1）, were measured by the Bio-Plex system. OLETF rats showed a significant increase in blood glucose, Hb A1c, creatinine, blood urea nitrogen（ BUN）, kidney/body weight ratio, glomerular area, 24 h-urine volume, urinary protein concentrations, MCP-1 and KIM-1 compared with LETO rats. There was a positive correlation not only between BUN and MCP-1 or KIM-1 but also between urinary protein concentrations and MCP-1 or KIM-1. These results indicate that the present OLETF rats have both glomerular and proximal tubular injury. Thus, the aged male OLETF rats with long-term diabetes may become a potent animal model for examining effects of exercise/dietary therapies on DCKD.},
 pages = {55--61},
 title = {糖尿病誘発性慢性腎疾患モデル動物―尿細管障害バイオマーカーによる検討―},
 volume = {68},
 year = {2021},
 yomi = {ヤスイ, トシヒデ and ハナオカ, トモコ and タカダ, ヨシヒロ and タケシタ, ダイスケ and ワシオ, ヒロエ and シンドウ, ダイスケ and ナカタニ, アキラ and サカタ, ススム}
}