| アイテムタイプ |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2009-10-10 |
| タイトル |
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|
タイトル |
Inhibition of hypertonic saline induced cough by Loratadine in nonasthmatic patients with chronic cough |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
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|
ID登録 |
10.14993/00000466 |
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ID登録タイプ |
JaLC |
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
田中, 繁宏
藤井, 達夫
平田, 一人
藤本, 繁夫
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
We examined the effect of loratadine（ 10mg） on the number of coughs induced by ultrasonically nebulized hypertonic saline in nine patients with chronic cough and in ten normal volunteers using a randomized， double- blind cross-over method. Each subject inhaled hypertonic saline for one minute， and the numbers of coughs during the one-minute 4.5% NaCl inhalation and the 30-second period following 4.5% NaCl inhalation were counted. There was no difference in forced expiratory volume in one second （ FEV1） or maximum expiratory flow at 25% vital capacity （ V25） before to after one-minute hypertonic saline inhalation for either patients or normal subjects. There was also no significant difference in FEV1 or V25 before to one hour after oral administration of loratadine. Placebo did not reduce the number of induced coughs for either patients or normal subjects， but loratadine significantly reduced the number of coughs for patients with chronic cough （P＝0.012）. On the other hand， loratadine did not reduce the number of coughs by normal subjects. We conclude that in patients with chronic cough， the release of histamine or other chemical mediators or high sensitivity of cough receptors to histamine may be one of the reasons for persistence of chronic cough. |
|
言語 |
en |
| 書誌情報 |
ja : 武庫川女子大学紀要. 自然科学編
en : The bulletin of Mukogawa Women's University. Natural science
巻 55,
p. 5-10,
発行日 2008-03-31
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| 出版者 |
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出版者 |
武庫川女子大学 |
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言語 |
ja |
| ISSN |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0916-3123 |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10187277 |
P05-10.pdf (1.8 MB)
