| アイテムタイプ |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2009-07-19 |
| タイトル |
|
|
タイトル |
高リン食摂取ラット腎ミトコンドリアの電子伝達系の損傷について |
| タイトル |
|
|
タイトル |
Damage of the electron transport chain of the kidney mitochondria of rats fed a high phosphorus diet |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
|
|
ID登録 |
10.14993/00000402 |
|
ID登録タイプ |
JaLC |
| 著者 |
岸本, 三香子
松浦, 寿喜
市川, 富夫
岸本, 三香子
Mathuura, Toshiki
Ichikawa, Tomio
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Five-week-old rats were fed on a diet containing phosphorus either at 0.3% (CD) or at 1.5% (HD) for 21 days. Mitochondrial fraction (MF) was obtained from the kidney by the usual method. Contents of calcium, magnesium and phosphorus in MF obtained from rats fed HD were significantly higher than those of CD. We investigated whether elevated mitochondrial calcium of rats fed HD induces changes in the oxidative phosphorylation system. Respiration of kidney mitochondria of rats fed HD was not induced by ADP. Mitochondrial dehydrogenase activity of rats fed HD induced by 0.5mM succinate and 0.4mM ADP was lower than that of rats fed CD. Mitochondrial respiration with NAD^+ -linked substrates like pyruvate, glutamate or malate was not induced by 0.4mM ADP in rats fed HD. Activity of complex II, Mg-dependent ATP-ase and isocitrate dehydrogenase of mitochondria of rars fed HD were lower than those of rats fed CD. The low activities of NADH reduction, complex II and ATPase in rat fed HD may cause to the lack of mitochondrial respiration. |
| 書誌情報 |
武庫川女子大学紀要. 自然科学編
巻 49,
p. 59-66,
発行日 2002-03-31
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0916-3123 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10187277 |
P059-066.pdf (601.5 kB)
