@article{oai:mukogawa.repo.nii.ac.jp:00000316, author = {堀江, 登 and HORIE, Noboru}, journal = {武庫川女子大学紀要. 自然科学編}, month = {Mar}, note = {This study was conducted to evaluate effects of alcohol-drinking in blood coagulation, fibrinolysis platelet and organ failure on endotoxin (LPS)-induced disseminated intravascular cogulation (DIC) in rats. Fibrinogen level, PT and APTT as the parameter of blood coagulation, α_2PI activity and FDP level as the fibrinolysis, AST(GOT) activity and BUN level as organ failure and platelet count were assayed. The increased AST(GOT) activity, shortened APTT, lowered fibrinogen level and decreased α_2PI activity was observed on the alcohol-drinking alone in comparison with non-drinking group. The parameters of DIC in blood coagulation, fibrinolysis, platelet and organ failure apparently grew worse more in LPS-induced DIC of alcohol-drinking group than in that of non-drinking group. There results indicate that LPS-induced DIC in rat may play a change for the worse with alcohol-drinking.}, pages = {69--74}, title = {エンドトキシンによって誘発された播種性血管内凝固症に対するアルコール摂飲の影響}, volume = {44}, year = {1997}, yomi = {ホリエ, ノボル} }