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アイテム
抗血小板薬シロスタゾールの神経細胞保護効果に関する基礎的研究
https://doi.org/10.14993/0002000847
https://doi.org/10.14993/000200084709b2dd6d-bdb9-4d5d-8d39-2a1b8ba40c15
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
P57-64.pdf (1.7 MB)
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| アイテムタイプ | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||||||
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| 公開日 | 2026-04-02 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | 抗血小板薬シロスタゾールの神経細胞保護効果に関する基礎的研究 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Basic research on the neuroprotective effects of the antiplatelet drug cilostazol | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 言語 | jpn | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||||||
| ID登録 | ||||||||||||||||||||||
| ID登録 | 10.14993/0002000847 | |||||||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||
| 著者 |
竹尾, 亜美
× 竹尾, 亜美
× 水野, 英哉
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| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Parkinsonʼs disease （PD） is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction and the excessive production of reactive oxygen species （ROS） play pivotal roles in its pathogenesis. Rotenone, a mitochondrial complex I inhibitor, has been widely used to induce oxidative stress and neuronal toxicity in cellular and animal models of PD. Cilostazol, an antiplatelet agent, exerts both antioxidant and neuroprotective effects. However, the detailed mechanism underlying its neuroprotective effects against rotenone-induced neurotoxicity remains unclear. In this study, we investigated the effects of cilostazol on rotenone-induced toxicity in human neuroblastoma SHSY5Y cells. Cilostazol did not prevent the reduction in cell viability or overall cytotoxicity induced by rotenone. Nevertheless, cilostazol suppressed the rotenone-induced activation of apoptotic pathways, including caspase-3 cleavage. Furthermore, cilostazol attenuated rotenone-induced ROS overproduction and, at lower concentrations, restored ROS levels close to those in control cells, suggesting that cilostazol does not completely protect against rotenone-induced cell death, and may exert neuroprotective effects by modulating ROS generation and inhibiting apoptotic signaling pathways. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 書誌情報 |
ja : 武庫川女子大学紀要 en : The bulletin of Mukogawa Women's University 巻 73, p. 57-64, 発行日 2026-03-05 |
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| 出版者 | ||||||||||||||||||||||
| 出版者 | 武庫川女子大学 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| ISSN | ||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 2759-2650 | |||||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||
| 収録物識別子 | AA12889706 | |||||||||||||||||||||
